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Scalpelectroporation®, also known as S.E.P for short, is a new breakthrough technology that is FDA approved as a true alternative to injections. Hailing from Italy, this incredible needle-free procedure allows the transdermal delivery of any substance the doctor or trichologist recommends.

In addition, it is the world’s ONLY truly needle-free transdermal delivery using varying pulse energy to delivery cell conditioned media into the scalp. This protocol is non-surgical, non-invasive and proven to improve serum absorption by 17X using breakthrough electroporation technology.

Due to the different typology and size of various molecules, not all substances are easily absorbed into the skin. For example, creams generally consist of larger sized molecules (a.k.a. macromolecules) and tend to sit at the superficial layers of the skin unable to permeate into the deeper dermal layers.

Scalpelectroporation® technology makes the skin tissues permeable to macromolecules, in a non invasive way, by utilizing the skin's water based channels to allow any ingredient to transdermally penetrate, using patented current pulses.

SEP Activator- Signature SEP Technology-1

How does S.E.P. compare to Electroporation and Iontophoresis?

Scalpelectroporation® allows both micro-molecules and macro- molecules to be safely delivered into the body without modification of the ionic drug solutions pH, Electrolysis effect of the ionic solution itself and the process causes no damage to tissue and cells, solving the problem traditional Ionthophoresis systems usually cannot.

SEP is also different from Electroporation which uses high voltages on the skin and can cause unwanted side effects on the patient. Instead, Scalpelectroporation® uses low electrical pulses that are controlled in value, time duration and electrical characteristics. It is safe, pain-free yet highly effective and patients find it completely comfortable.

Previously, macromolecules (1-2mil dalton) were not able to be delivered transdermally using traditional Ionthophoresis, but now such substances can successfully be delivered using SEP technology.

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What kinds of substances can be driven using SEP technology?

At Papilla Haircare, we utilize SEP technology to deliver the following drugs for scalp treatments:

  Salmon PDRN

  SOD Antioxidant Complex™

 Botanical Cell Extracts

   Growth factors



 Red Clover Extract

  Hyaluronic Acid



 Amino Acids




What types of hair loss can the SEP treatment target and what are the key advantages?

tick Icon one  All types of scalp conditions including Alopecia Type 1 and 2 and Hamilton classifications 3 to 5.
tick Icon two  Suitable for all scalp types
tick Icon three  Dermatologist tested
tick Icon four   Scientifically formulated
tick icon five   Lab certified
tick icon six  Based on Clinical trial data
tick icon seven  Cell rejuvenation using EV-cytokine technology



tick icon one  Non-invasive and Needle-free
tick icon two   No electrodes hence no electrolysis reaction
tick icon three  Direct transfer of active ingredients through the skin without any needles
tick icon four   Minimal pain
tick icon five  No damage to tissue and cells
tick icon six   Safe
tick icon seven   Improves serum absorption by 17X
tick Icon eight   Controlled, precise and homogeneous drug delivery
tick icon nine   Capable of transdermal delivery of macromolecules



Delivery modes comparison


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Is the treatment suitable for pregnant moms?

Although the SEP Activator for hair loss treatment is a safe device, it is not recommended for pregnant women.

Is the treatment suitable for breastfeeding moms?

The SEP Activator for hair loss treatment delivers serums to the subcutaneous level and not to the blood stream. Hence it is safe for breastfeeding moms. The only product to avoid is Papilla's Daily Scalp Mask which contains acids. Please let our therapists know if you are breastfeeding so that we are aware of what products to avoid.

Is the treatment painful?

You may experience a tingling sensation as the treatment is performed. Many clients find it comfortable and relaxing.


Is the treatment invasive?

No. The treatment is non-invasive, non-ablative and needle-free.


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